UT Arlington professor awarded $1.9 million to study hospital infection
A UT Arlington microbiologist developing a treatment for one of the most widespread hospital infections in the U.S. has been awarded $1.9 million in funding from the National Institutes of Health National Center for Complementary and Alternative Medicine.
Julian Hurdle, an assistant professor of biology, plans to study the effect of reutericyclin compounds on the bacteria Clostridium difficile is the leading cause of diarrhea in elderly hospital and nursing home patients. It also affects cancer patients and others with compromised immune systems. There are more than 500,000 cases each year and 15,000 to 20,000 deaths.
“Developing treatments to combat serious public health threats such as hospital infections is the type of research work that occurs at national research universities like UT Arlington,” said Ron Elsenbaumer, UT Arlington Vice President for Research. “Dr. Hurdle’s work could be the first step toward a valuable new therapy that will help save lives.”
Reutericyclin is an antimicrobial compound produced naturally by a probiotic organism called Lactobacillus reuteri infections have become more widespread and difficult to treat over the past ten years, with high rates of relapse,” said Hurdle, who joined the UT Arlington College of Science in 2010. “With only a few drugs available to treat it, there is a great clinical need and a market opportunity in developing treatments for C. difficile at achievable colonic concentrations.”
Hurdle and Lee also believe that reutericyclins could be used to coat the surface of biomedical implants to prevent contamination of devices with bacteria such as MRSA and Staphylococcus epidermidis. Those bacteria cause persistent infections responsible for the failure of several commonly used medical implants.
Hurdle’s work is an example of the cutting-edge research going on at The University of Texas at Arlington, a comprehensive research institution of 33,800 students in the heart of North Texas. Visit www.uta.edu to learn more.
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His co-investigator on the project is Richard Lee, a medicinal chemist and faculty member at St. Jude Children's Research Hospital in Memphis, Tenn. C. difficile is the leading cause of diarrhea in elderly hospital and nursing home patients.
Xenex systems are currently being used by hospitals throughout the US and have been proven to be effective against a variety of the most dangerous superbugs, including Clostridium difficile endospores (C. diff), MRSA, VRE, and Acinetobacter.
"Xenex's technology enables Sodexo to confidently provide a healthy healing environment to the patients, visitors and staff we serve more quickly and more effectively than any other technology on the market," said John LaRochelle, vice president of
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